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Re-irradiation for recurrent NPC—is the treatment merited at all?

	author = {Edwin Wong and Jessica Hung and Wai-Tong Ng},
	title = {Re-irradiation for recurrent NPC—is the treatment merited at all?},
	journal = {Annals of Nasopharynx Cancer},
	volume = {2},
	number = {5},
	year = {2018},
	keywords = {},
	abstract = {With advances in radiotherapy (RT) technique and chemotherapy strategies, the survival of patients with nasopharyngeal carcinoma (NPC) has improved substantially in the past few decades, with most intensity-modulated radiation therapy (IMRT) series achieving up to 90% loco-regional control (1). The most common site of recurrence remains to be distant. Local recurrence of NPC, albeit uncommon, is extremely debilitating and difficult to manage. Salvage surgery and re-RT are the only curative treatment options available. Randomized study to compare surgery and re-RT is deemed difficult due to the rarity of the condition and the heterogeneity of this heavily pre-treated population. Treatment choice is, therefore, mainly based on each physician’s discretion, availability of expertise and patient’s choice.},
	url = {}